Originally Posted by CanarsieBK
but I'd say to definitely focus on one topic and kill it on that topic.
I agree with CanarsieBK in focusing on one topic.
Which topic out of the two do you think you will bring unique perspectives to the audience?
If it is web design, then you can focus on things like techniques, tutorials, and samples.
If it is running a business from home, then you can cover business aspects, domain names, hosting, marketing tips, and of course you will mention about web design as well.
Make a pick depending on who your primary audience is
You can also start off with one blog, then buy another domain and develop your other topic. It will make things easier if you know who you are trying to reach.