It depends on a lot of factors, including what you're selling, who your customers are, how good you are at setting up ecommerce sites, how good you are at promoting the site, how much you know about conversion optimization, etc.
Whether you use a site builder or use a content management system or code the whole thing by hand in HTML is probably one of the least significant factors in whether an ecommerce site will be successful.
To find out more about the features and processes that are most often successful, you might want to try running some searches on topics such as "conversion optimization" and "user experience optimization". If your chosen website builder doesn't let you set things up the way you believe will work best for your customers, find another alternative. There are plenty of choices out there; no reason to use an option that makes it harder for you to close the sale.